Fig. 3.
Computational model of functional connectivity. (A) Scatter plot of empirical rsFC versus simulated rsFC obtained from the nonlinear model, down-sampled to the low resolution. (B) Comparison of SC, rsFC (empirical), and rsFC (nonlinear model) for 2 single-seed regions, the posterior cingulate in the right hemisphere (rPC) and the precuneus in the left hemisphere (lPCUN). The plot displays SC and rsFC values for the seed regions in relation to all 66 regions within the corresponding low-resolution matrices. (C) Mapping of SC, rsFC (empirical), and rsFC (modeled) within the DMN. Warmer colors indicate stronger SC and rsFC. Within the posterior cingulated/precuneus, medial orbitofrontal cortex and lateral parietal cortex in both hemispheres we selected a cluster of 5 ROIs at positions that most closely matched the coordinates of peak foci of the DMN (31). These 30 ROIs served as the seeds from which SC and rsFC were determined. (D) Structural connectivity within the DMN. We selected the top 200 most correlated ROIs within the DMN (see Fig. S5D) and plotted all structural connections among them.