Figure 2.
Behavioral findings emerging from a probabilistic reward task involving a differential reinforcement schedule. Response bias toward the more frequently rewarded stimulus was reduced in (a) unmedicated MDD subjects (Pizzagalli et al. 2008b); (b) healthy controls performing the task under acute stressor (Bogdan & Pizzagalli 2006); and (c) healthy controls receiving a single dose of a D2/3 agonist hypothesized to reduce phasic DA signaling to reward outcomes via presynaptic DA autoreceptor activation (Pizzagalli et al. 2008a).