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. 2016 Jun 15;6:27964. doi: 10.1038/srep27964

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All nodes are visualized as spheres and size is weighted by individual normalized degree/BC. Non-hubs are coloured in blue, green spheres are hubs specific to HCs, red spheres are hubs specific to MDD patients, and yellow spheres are hubs in common. Degree hubs specific to HCs (green): fusiform, inferior temporal gyrus and insula in the left hemisphere; and inferior temporal gyrus, transverse temporal gyrus and insula in the right hemisphere. Degree hubs specific to MDD patients (red) include: caudal anterior cingulate gyrus, cuneus gyrus, isthmus of the cingulate cortex, posterior cingulate cortex and rostral anterior cingulate cortex in the left hemisphere; and fusiform, isthmus of the cingulate cortex, lateral orbitofrontal gyrus and parahippocampal gyrus in the right hemisphere. Degree hubs in common (yellow): lateral orbitofrontal gyrus in the left hemisphere; and caudal anterior cingulate cortex, and medial orbitofrontal gyrus in the right hemisphere. Completely non-overlapping betweenness hubs were identified by comparing HCs with MDD patients. Betweenness hubs specific to HCs: banks of the superior temporal sulcus, lingual gyrus, middle temporal gyrus, pars opecularis and supra-marginal gyrus in the left hemisphere; and caudal middle frontal gyrus, superior temporal gyrus, transverse temporal gyrus and insula in the right hemisphere. Betweenness hubs specific to MDD patients: inferior parietal gyrus, isthmus of the cingulate cortex and parahippocampal gyrus in the left hemisphere; and isthmus of the cingulate cortex, rostral anterior cingulate cortex, supra-marginal gyrus and temporal pole in the right hemisphere.